Acetazolamide: in ventilator weaning

The following articles have been identified following the ward round on Friday 9th June 2017 to provide some reading around the role of Acetazolamide in ventilator weaning.

If you have any problems accessing these documents please use your NHS Athens or contact library.rph@lthtr.nhs.uk

Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial. Faisy et al. JAMA. 2016 Feb 2;315(5):480-8

Comments on the above:

Acetazolamide and Invasive Mechanical Ventilation for Patients With COPD. [JAMA. 2016]

Acetazolamide and Invasive Mechanical Ventilation for Patients With COPD–Reply. [JAMA. 2016]

Acetazolamide and Invasive Mechanical Ventilation for Patients With COPD. [JAMA. 2016]

Effects of early administration of acetazolamide on the duration of mechanical ventilation in patients with chronic obstructive pulmonary disease or obesity-hypoventilation syndrome with metabolic alkalosis. A randomized trial. Rialp et al. Pulm Pharmacol Ther. 2017 Jun;44:30-37.  Abstract only.

Acetazolamide: a second wind for a respiratory stimulant in the intensive care unit? Heming et al. Critical Care 2012, 16:318 

Effectiveness of acetazolamide for reversal of metabolic alkalosis in weaning COPD patients from mechanical ventilation. Faisy et al. Intensive Care Med. 2010 May;36(5):859-63.  Abstract only