Methylene blue complications

The following articles have been identified following the ward round on Friday 9th June 2017 to provide some reading around the use of methylene blue (methylthioninium chloride) and complications with anaesthesia.

If you have any problems accessing these documents please use your NHS Athens or contact


Methylthioninium chloride Proveblue 5 mg/ml solution for injection EMC 2016

Hypertension and Decreased Renal Blood Flow Following Methylene Blue Injection Birch, A; Boyce, W Anesthesia & Analgesia: September/October 1976

Risk of severe serotonin toxicity following co-administration of methylene blue and serotonin reuptake inhibitors: an update on a case report of post-operative delirium. Stanford et al. J Psychopharmacol. 2010 Oct;24(10):1433-8

Fatal methylene blue associated serotonin toxicity Top et al. Netherlands. The Journal of Medicine April 2014. 72 (3) 


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